Controlled Data Releases

EpUp Study: A Pilot Intervention for People with Epilepsy & Depression

Hum, K. M., Chan, C. J., Gane, J., Conway, L., McAndrews, M. P., & Smith, M. L.
About one third of people with epilepsy experience comorbid depression. UPLIFT (Using Practice and Learning to Increase Favorable Thoughts) uses mindfulness-based cognitive behavioural therapy (CBT) principles to treat depression in people with epilepsy. The EpUp study aimed to examine outcomes of UPLIFT versus EpINFO, an epilepsy information and self-management program. The effects of these distance-delivery, group intervention programs were studied in adults with epilepsy and self-reported depressive symptoms...

Version: 1.0 Date Released: 2022-11-25
Participants: 66 Files: 240 Size: 10.13 MB

Cohorts: UpLift, EpInfo, Wait-List Control

Timepoints: Pre Waitlist (T1), Pre Intervention (T1/T1a), Post Intervention (T2), Short Term Followup (T3), Long Term Followup (T4)

Modalities: Clinical studies, Distance-delivery, Group intervention, Mindfulness cognitive behavior therapy, Self-management

Formats: CSV

For further information

Do distance-delivery group interventions improve depression in people with epilepsy?

Hum KM, Chan CJ, Gane J, Conway L, McAndrews MP & Smith ML (2019). Epilepsy & behavior.

CP-NET: Hemi-NET Clinical Database

Cerebral Palsy Neuroscience Discovery Network (CP-NET)
This controlled data release focuses on CP-NET's initial Clinical Database which solely focused on children and youth, aged 2-18, with a confirmed diagnosis of hemiplegic cerebral palsy (CP). The Hemi-NET Clinical Database has data on 320 children and youth from across Ontario...

Version: 1.0 Date Released: 2022-10-17  
Participants: 320 Files: 14 Size: 47.24 GB

Conditions: Cerebral palsy, hemiplegic

Scans: MR-T1w, MR-T2w, MR-FLAIR, DTI, Angio, CT, MR-PDT2, MR-PDw, MRS

Timepoints: Phase 1 Data - Single Time Point

Modalities: Genomics, clinical studies, patient registry, neuroimaging

Formats: CSV, BVAL, BVEC, NIfTI, PDF, CEL, CYHD.CYCHP

For further information

Neurodevelopmental profiles of children with unilateral cerebral palsy associated with middle cerebral artery and periventricular venous infarctions.

Fehlings D, Krishnan P, Ragguett RM, deVeber G, Gorter JW, Hunt C, Kim M, Mesterman R. McCormick A & CP-NET Group (2021). Dev Med Child Neurol.


Additional Resources

About CP-NET Hemi-NET CP-NET Videos


Province of Ontario Neurodevelopmental Disorders Network (POND) Imaging Data

Dr. Evdokia Anagnostou, Dr. Jason Lerch, Dr. Paul D. Arnold, Dr. Rob Nicolson, Dr. Stelios Georgiades, Dr. Stephen W. Scherer, Dr. Russell Schachar, Dr. Jennifer Crosbie, Dr. Peter Szatmari, Dr. Xudong Liu, Dr. Elizabeth Kelley, Dr. Muhammad Ayub and Dr. Karun Singh. POND Network
The Province of Ontario Neurodevelopmental Disorders (POND) Network is an Integrated Discovery Program funded by the Ontario Brain Institute and aims to understand the neurobiology of neurodevelopment disorders and translate the findings into effective new treatments...

Version: 1.0 Date Released: 2022-02-22 ARK ID: 70798/d7qv7rj6b98w66v7m3
Participants: 2784 Files: 15 Size: 1.0 GB

Conditions: ADHD, Autism spectrum disorder, Obsessive-compulsive disorder, Anxiety, Fragile X syndrome, 22q11.2 deletion syndrome, Tourette's syndrome

Scans: MR-T1 & MR-T2 (anatomy), DTI (resting state), MRS, MRS (GABA-ACC), MEG (resting state), GRE

Tasks: Emotion processing fMRI task paradigm (faces), Social cognition (theory of mind) fMRI task, Stop signal task (fMRI), Set-shifting task (MEG), Go/no-go task (MEG), Social attribution task (MEG), Inscape task (MEG)

Timepoints: Single Timepoint

Modalities: Genetics, Neuroimaging, MRI, MEG, Neurobiology

Formats: CSV

For further information

Oxytocin receptor polymorphisms are differentially associated with social abilities across neurodevelopmental disorders.

Baribeau DA, Dupuis A, Paton TA, Scherer SW, Schachar RJ, Arnold PD, Szatmari P, Nicolson R, Georgiades S, Crosbie J, Brian J, Iaboni A, Lerch J & Anagnostou E (2017). Scientific reports.

Integrated Biological Markers for the Prediction of Treatment Response in Depression

Dr. Sidney Kennedy, Dr. Pierre Blier, Dr. Faranak Farzan, Dr. Benicio Frey, Dr. Jane Foster, Dr. Raymond Lam, Dr. Glenda MacQueen, Dr. Roumen Milev, Dr. Daniel Mueller, Dr. Sagar Parikh, Dr. Susan Rotzinger, Dr. Stephen Strother, Dr. Claudio Soares, Dr. Valerie Taylor, Dr. Gustavo Turecki, Dr. Rudolf Uher, and the CAN-BIND Study Team
The Canadian Biomarker Integration Network in Depression (CAN-BIND) is a national program of research and learning. From 2013 to 2017, data were collected from 211 participants with major depressive disorder and 112 healthy individuals...

Version: 1.0 Date Released: 2021-09-12 ARK ID: 70798/d7v9bn9dj0pkm2rb7j
Participants: 323 Files: 3740 Size: 4.16 GB

Cohorts: Major Depressive Disorder, Healthy Controls

Scans: EEG (resting state), fMRI (resting state), DTI, T1W

Tasks: Emotional Face Categorization/Conflict Task (fMRI), go/no-go task (fMRI), anhedonia task (fMRI)

Timepoints: Baseline only (additional timepoints coming soon)

Modalities: fMRI, Structural MRI, Diffusion tensor imaging, Electroencephalography, Genomics, Metabolomics, Methylation, Inflammatory markers

Formats: BVAL, BVEC, CSV, EDAT, EDF, FDT, NIfTI, SET

For further information


Ontario Neurodegenerative Disease Research Initiative (ONDRI): Foundational Study Baseline Data - Release 1

Dr. Mario Masellis, Dr. Douglas Munoz, Dr. Michael Strong, Dr. Richard Swartz, ONDRI study team
ONDRI's Foundational study includes data from 520 people living with Alzheimer’s Disease, Mild Cognitive Impairment, Parkinson’s Disease, Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, or Cerebrovascular Disease, along with their care partners...

Version: 1.0 Date Released: 2022-06-08 ARK ID: 70798/d7r439px587bx4v6vq
Participants: 520 Files: 176 Size: 10.85 MB

Conditions: Alzheimer's disease, Cognitive impairment, Parkinson's disease, Amyotrophic lateral sclerosis, Frontotemporal dementia, Unspecified cerebrovascular disease

Timepoints: Baseline, Screening (additional timepoints coming soon)

Modalities: Cohort study, clinical, Cognitive, Gait and balance, Eye tracking, Retinal imaging, Genetic markers, Neuroimaging, Neuropsychological assessment, Cross-disease, Cross-platform, Caregiver, Deep pheotyping

Formats: CSV, TXT

For further information

Characteristics of the Ontario Neurodegenerative Disease Research Initiative cohort.

Sunderland KM, Beaton D, Arnott SR, Kleinstiver P, Kwan D, ,Lawrence-Dewar JM, Ramirez J, Tan B, Bartha R & Black SE (2022). Alzheimer's & Dementia.

Province of Ontario Neurodevelopmental Disorders Network (POND) Registry Clinical Data

Dr. Evdokia Anagnostou, Dr. Jason Lerch, Dr. Paul D. Arnold, Dr. Rob Nicolson, Dr. Stelios Georgiades, Dr. Stephen W. Scherer, Dr. Russell Schachar, Dr. Jennifer Crosbie, Dr. Peter Szatmari, Dr. Xudong Liu, Dr. Elizabeth Kelley, Dr. Muhammad Ayub and Dr. Karun Singh. POND Network
The Province of Ontario Neurodevelopmental Disorders (POND) Network is an Integrated Discovery Program funded by the Ontario Brain Institute, and aims to understand the neurobiology of neurodevelopment disorders and translate the findings into effective new treatments. Neurodevelopmental disorders investigated as part of this program include attention deficit/hyperactivity disorder, autism spectrum disorder, intellectual disability, obsessive compulsive disorder, Tourette syndrome, Rett syndrome, Down syndrome, Fragile X syndrome and any other genetic differences associated with neurodevelopmental disorder difficulties...

Version: 1.0 Date Released: 2021-05-03 ARK ID: 70798/d7tm3tfvt75mn87bjq
Participants: 2784 Files: 15 Size: 1.2 GB

Conditions: ADHD, Autism spectrum disorder, Intellectual Disability, Obsessive-compulsive disorder, Anxiety, Rett Syndrome, Down's Syndrome, Fragile X syndrome, 22q11.2 deletion syndrome, Tourette's syndrome, Social (pragmatic) communication disorder

Timepoints: Registry

Modalities: Patient registry, Clinical studies

Formats: CSV

For further information

Oxytocin receptor polymorphisms are differentially associated with social abilities across neurodevelopmental disorders. Scientific reports.

Baribeau DA, Dupuis A, Paton TA, Scherer SW, Schachar RJ, Arnold PD, Szatmari P, Nicolson R, Georgiades S, Crosbie J, Brian J, Iaboni A, Lerch J & Anagnostou E (2017). Scientific Reports.

5P: Predicting Persistent Postconcussive Problems in Pediatrics

Dr. Roger Zemek, Dr. Martin Osmond and the Pediatric Emergency Research Canada (PERC) Concussion Team
Concussion is a common injury occurring in children and adolescents, and results in a wide variety of effects spanning physical, cognitive (thinking), psychological/behavioural, or sleep. While most cases of concussion improve within weeks, approximately one third of children have on-going symptoms for longer than 1 month, known as persistent post concussive symptoms (PPCS)...

Version: 1.0 Date Released: 2021-05-03 ARK ID: 70798/d7br8mdvk9k9x2bd4x
Participants: 3063 Files: 2 Size: 141 MB

Conditions: Concussion

Timepoints: Enrollment, Week 1 Follow-up, Week 2 Follow-up, Week 4 Follow-up, Week 8 Follow-up, Week 12 Follow-up

Modalities: Clinical studies

Formats: CSV

For further information

Predicting and preventing postconcussive problems in paediatrics (5P) study: protocol for a prospective multicentre clinical prediction rule derivation study in children with concussion.

Zemek R, Osmond MH & Barrowman N for PERC Concussion Team. (2013) BMJ Open.

Clinical Risk Score for Persistent Postconcussion Symptoms Among Children With Acute Concussion in the ED.

Zemek R, Barrowman N, Freedman S, et al. for the Pediatric Emergency Research Canada (PERC) Concussion Team. (2016). JAMA.


Additional Resources

About 5P 5P Publications